High-Throughput Electrochemical Delamination of Two-Dimensional Covalent Organic Frameworks

, yielding crystalline nanosheets that are readily dispersible across various solvents including water. Principal component analysis reveals solvent permittivity and polarity, along with film wettability, as critical factors governing the delamination efficiency. Complementary diffraction, spectroscopy, and electron microscopy studies elucidate a synergistic delamination mechanism involving molecular preintercalation, framework protonation, and electrolysis-driven gas evolution. Leveraging the intrinsic microporosity and excellent solution processability of these nanosheets, we demonstrate their utility in producing membranes for efficient antibiotic desalination. This work advances the scalable synthesis of crystalline COF nanosheets, broadening the application toolkit of COFs.