生物膜
阳离子聚合
化学
细菌
生物
有机化学
遗传学
作者
Xinbei Du,Mengke Ma,Yahan Zhang,Xian‐Min Yu,Longming Chen,Han Zhang,Zhao Meng,Xueshun Jia,Junyi Chen,Qingbin Meng,Chunju Li
标识
DOI:10.1002/anie.202301857
摘要
Since bacteria in biofilms are inherently resistant to antibiotics and biofilm-associated infections pose a serious threat to global public health, new therapeutic agents and schemes are urgently needed to meet clinical requirements. Here two quaternary ammonium-functionalized biphen[n]arenes (WBPn, n=4, 5) were designed and synthesized with excellent anti-biofilm potency. Not only could they inhibit the assembly of biofilms, but also eradicate intractable mature biofilms formed by Gram-positive S. aureus and Gram-negative E. coli bacterial strains. Moreover, they could strongly complex a conventional antibiotic, cefazolin sodium (CFZ) with complex stability constants of (7.41±0.29)×104 M-1 for CFZ/WBP4 and (4.98±0.49)×103 M-1 for CFZ/WBP5. Combination of CFZ by WBP4 and WBP5 synergistically enhanced biofilm eradication performance in vitro and statistically improved healing efficacy on E. coli-infected mice models, providing a novel supramolecular strategy for combating biofilm-associated infections.
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