Vision-Related Quality of Life After Fyodorov–Zuev Keratoprosthesis in China

Purpose: The purpose of this study was to assess vision-related quality of life (VR-QoL) and its determinants in patients with implanted Fyodorov–Zuev (MICOF) KPro. Methods: Eighty-eight patients with bilateral corneal blindness who underwent unilateral Fyodorov–Zuev (MICOF) KPro implantation were included in this cross-sectional study. VR-QoL was assessed using the National Eye Institute Visual Function Questionnaire-25 (NEI-VFQ-25). Univariate analyses and multivariate linear regression were used to identify VR-QoL determinants. Results: Eighty-eight patients, aged 50.00 ± 13.72 years, with a mean postoperative time of 5.13 ± 3.31 years, were included. The composite NEI-VFQ-25 score improved from 17.04 ± 5.60 to 46.00 ± 19.21 ( P < 0.01) after Fyodorov–Zuev (MICOF) KPro implantation. The multivariate linear regression analysis results showed that the postoperative composite score was correlated with postoperative visual acuity (VA) of the operative eye (B = −21.66, P < 0.01). Improvement in NEI-VFQ scores was associated with better postoperative VA of the operative eye (B = −18.67, P < 0.01) and poorer preoperative VA of the fellow eye (B = 7.11, P < 0.05). Conclusion: VR-QoL in patients with bilateral corneal blindness was significantly impaired but improved after Fyodorov–Zuev (MICOF) KPro implantation. Improvement in VR-QoL was inversely associated with postoperative VA of the operative eye but positively correlated with preoperative VA of the fellow eye. This study affirmed that Fyodorov–Zuev (MICOF) KPro was an effective alternative for patients with corneal blindness with respect to VR-QoL.