Experimental study of Crateagus pinnatifida on hyperlipidemia prevention and treation

Objective To investigate the effect of Crateagus pinnatifida on hyperlipidemia prevention and treation.Methods The hyperlipidemia model in rats was set up by feeding with high cholesterol diet.After having been treated for one month,blood-fat levels(TC,TG,LDL-C and HDL-C)in serum were measured;the rats were sacrificed and the aortas were collected for pathological changes.The levels of TNF-α,IL-6 and ICAM-1 in serum were also measured by ELISA.Results Crateagus pinnatifida could significantly decrease the con-tents of serum TC,TG and LDL-C,and reduce the score of pathological changes of the hyperlipidemia,while the level of HDL-C was increased as compared with that of model group(P 0.05 or P 0.01).Conclusion The results indicate that Crateagus pinnatifida can inhibit experimental hyperlipidemia,and prevent the formation of hyperlipidemia.