Lymphangiogenesis and Lymphatic Metastasis in Tumor

Lymphatic metastasis is an important route of tumor metastasis.The structural features of lymphatic system are anatomical basis for lymphatic metastasis.The markers of lymphatic vessel can facilitate the identifiction of lymphangiogenesis.Lymphangiogenesis has been found in the intratumorous and peritumorous tissues of many malignancies.The density of neogenetic lymphatics and the expression levels of molecular markers of lymph duct are closely related to lymphatic metastasis.The study of VEGF(vascular endothelial growth factor)family provides a new approach to reveal the the mechanism of lymphatic metastasis.This article reviews the studies on tumor lymphangiogenesis and the mechanism of lymphatic metastasis.