Observation on clinical efficacy of Qingxuetang combined with allopurinol treating renal hyperuricemia

[Objective] Curative effect of Qingxuetang combined with different dose of allopurinol in treating renal hyperuricemia. Try to reduce the dose of allopurinol on the basis of traditional Chinese medicine for reducing allopurinol's adverse reactions. [Methods] Ninty patients were randomly divided into three groups, with 30 cases in each group. On basis of routine treatment and Qingxuetang treatment, each group was separately given 150 mg allopurinol, 100 mg allopurinol, 50 mg allopurinol. We observe the chang of Scr、BUN、GFR、UA and symptom score at 0、2、4、8 week. [Results] The total curative effect of three groups were no statistically significant difference(P0.05). Scr, BUN, GFR and symptom score in each group was no statistically significant difference(P 0.05). In reducing UA aspect, Qingxuetang combined with allopurinol 100 mg was no statistically significant difference as allopurinol 150 mg(P 0.05). Qingxuetang combined with allopurinol 50 mg reducing UA was less than with allopurinol 150 mg(P0.05). The cases of Qingxuetang combined with allopurinol 100 mg having adverse reactions were less than with allopurinol 150 mg,and degree of adverse reaction was lighter than with allopurinol 150 mg.[Conclusion] The three groups were no statistically significant differences in improvement of renal function and clinical symptoms in renal hyperuricemia. In reducing UA aspect, Qingxuetang combined with allopurinol 100 mg can replace Qingxuetang combined with allopurinol 150 mg. Qingxuetang combined with allopurinol 100 mg was better effective and security than with allopurinol 150 mg.