富勒烯
化学
激进的
动力学
溶解度
螯合作用
离子交换
有机化学
组合化学
离子
量子力学
物理
作者
Qingchun Zhang,Bo Jin,Xiaofang Wang,Lei Shan,Qiangqiang Liu,Hua Liang,Shijin Chu,Rufang Peng
标识
DOI:10.1002/slct.201702049
摘要
Abstract Radionuclide internal contamination can induce chemical and radiological intoxication and produce harmful free radicals in vivo . Conventional studies on chelating agents have disregarded the damage of free radicals to the body. Therefore, novel poly‐hydroxypyridinone fullerene derivatives were designed and prepared by using chlorofullerene as precursor. The poor water solubility of fullerene was ameliorated by chemically modifying of hydrophilic hydroxypyridinone, and obtaining high Water‐soluble fullerene derivatives. The radical scavenging reaction kinetics of target products were studied. They all exhibited much higher rate constants than other fullerene polymer system. The Ce III ion was used as a simulated radionuclide for evaluating the binding ability of target products, and the values of conditional stability constants were about 5.15‐6.11. Thus, the bifunctional, Water‐soluble fullerene derivatives were successfully generated. The results provided basis for further study on the potential application of poly‐hydroxypyridinone fullerene derivatives as radionuclide chelators.
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