Perampanel in cases of refractory temporal lobe epilepsy – A report of two post-operative and two eligible for temporal lobectomy

• TL is a surgical procedure. • Parampanel was given in 2 surgical failures, and 2 listed for surgery. • There was significant control in seizures in all the four cases with Perampanel as a single add on to ongoing refractory state. Temporal Lobectomy (TL) is an accepted surgical procedure for refractory seizures. To assess the effects of Perampanel (PER) therapy in patients with refractory temporal lobe epilepsy. Perampanel therapy was administered in two cases with refractory seizures post temporal lobectomy and in two others with refractory seizures who were eligible for temporal lobectomy. There was significant control in seizures in all the four cases with Perampanel as a single add on to ongoing refractory state.