亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

The Effect of Dihydromyricetin, a Natural Flavonoid, on Morphine-induced Conditioned Place Preference and Physical Dependence in Mice

吗啡 有条件地点偏好 身体依赖 药理学 (+)-纳洛酮 跳跃的 化学 类阿片 受体 医学 内科学 生理学
作者
Leila Etemad,Hadi Farkhari,Mohaddeseh Sadat Alavi,Ali Roohbakhsh
出处
期刊:Drug research [Thieme Medical Publishers (Germany)]
卷期号:70 (09): 410-416 被引量:7
标识
DOI:10.1055/a-1206-6757
摘要

Abstract Objective Dihydromyricetin (DHM), a natural flavonoid, is used to reduce alcohol hangover. It has a modulatory role on GABAA receptors with significant effects on seizure and anxiety in animal models. We aimed to evaluate the effect of DHM on morphine conditioned place preference (CPP) and withdrawal sings following morphine dependence using animal models. Methods The effect of DHM (1, 2 and 5 mg/kg, intraperitoneal; ip) on the acquisition and expression of morphine-induced CPP was evaluated in male mice. Administration of morphine for three consecutive days induced physical dependence. The withdrawal signs such as jumping and defecation were precipitated by administration of naloxone (8 mg/kg, ip). The effect of DHM on the development of physical dependence was assessed by injection of DHM before morphine administrations. Results DHM, at the dose of 5 mg/kg, reduced expression of morphine CPP with an increase in the locomotor activity. DHM, at the doses of 2 and 5 mg/kg, also reduced development of morphine CPP. DHM alleviated development of morphine-induced physical dependence at the dose of 1, 2, and 5 mg/kg by decreasing jumping and defecation. Conclusion These results indicated that DHM decreased acquisition and expression of morphine CPP and inhibited development of morphine-induced physical dependence.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
2秒前
Jasper应助科研通管家采纳,获得10
29秒前
1分钟前
小邓发布了新的文献求助10
1分钟前
方俊驰完成签到,获得积分10
1分钟前
慕青应助小邓采纳,获得10
1分钟前
weihe完成签到 ,获得积分10
2分钟前
2分钟前
2分钟前
ZGHKY发布了新的文献求助10
2分钟前
Anfakh发布了新的文献求助10
2分钟前
andrele应助科研通管家采纳,获得10
2分钟前
2分钟前
喜乐发布了新的文献求助10
2分钟前
zzgpku完成签到,获得积分0
2分钟前
3分钟前
小邓发布了新的文献求助10
3分钟前
4分钟前
柔弱烨霖发布了新的文献求助10
4分钟前
andrele应助科研通管家采纳,获得10
4分钟前
4分钟前
范振杰完成签到,获得积分20
5分钟前
范振杰发布了新的文献求助10
5分钟前
领导范儿应助范振杰采纳,获得10
5分钟前
6分钟前
忧郁小鸽子完成签到,获得积分10
8分钟前
科研通AI5应助科研通管家采纳,获得10
8分钟前
小马甲应助budingman采纳,获得10
8分钟前
小二郎应助budingman采纳,获得10
8分钟前
顾矜应助budingman采纳,获得10
8分钟前
共享精神应助budingman采纳,获得10
8分钟前
深情安青应助budingman采纳,获得10
8分钟前
CipherSage应助budingman采纳,获得10
8分钟前
8分钟前
柔弱烨霖发布了新的文献求助10
8分钟前
9分钟前
852应助budingman采纳,获得10
9分钟前
领导范儿应助budingman采纳,获得10
9分钟前
香蕉觅云应助budingman采纳,获得10
9分钟前
汉堡包应助budingman采纳,获得10
9分钟前
高分求助中
Technologies supporting mass customization of apparel: A pilot project 600
Introduction to Strong Mixing Conditions Volumes 1-3 500
Tip60 complex regulates eggshell formation and oviposition in the white-backed planthopper, providing effective targets for pest control 400
A Field Guide to the Amphibians and Reptiles of Madagascar - Frank Glaw and Miguel Vences - 3rd Edition 400
China Gadabouts: New Frontiers of Humanitarian Nursing, 1941–51 400
The Healthy Socialist Life in Maoist China, 1949–1980 400
Walking a Tightrope: Memories of Wu Jieping, Personal Physician to China's Leaders 400
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 物理 生物化学 纳米技术 计算机科学 化学工程 内科学 复合材料 物理化学 电极 遗传学 量子力学 基因 冶金 催化作用
热门帖子
关注 科研通微信公众号,转发送积分 3798503
求助须知:如何正确求助?哪些是违规求助? 3343980
关于积分的说明 10318286
捐赠科研通 3060565
什么是DOI,文献DOI怎么找? 1679670
邀请新用户注册赠送积分活动 806731
科研通“疑难数据库(出版商)”最低求助积分说明 763323