肝细胞癌
癌症研究
癌变
下调和上调
基因敲除
细胞生长
体内
生物
化学
癌症
生物化学
细胞凋亡
基因
遗传学
作者
Zhi Lv,Ge Ma,Zhuo Zhong,Xiong Xie,Bin Li,De Liang
标识
DOI:10.1093/carcin/bgad034
摘要
Abstract Ras-related protein Rab-10 (RAB10) is involved in tumorigenesis and progression of hepatocellular carcinoma (HCC). Here, we found RAB10, O-GlcNAc transferase (OGT), and O-GlcNAcylation were upregulated in HCC. In addition, RAB10 protein level was prominently positively correlated with the expression of OGT. O-GlcNAcylation modification of RAB10 was then investigated. Here we showed that RAB10 interacts directly with OGT in HCC cell lines, Meanwhile, O-GlcNAcylation enhanced RAB10 protein stability. Furthermore, knockdown of OGT suppressed aggressive behaviors of HCC in vitro and in vivo, while elevated RAB10 reversed these. Taken together, these results indicated that OGT mediated O-GlcNAcylation stabilized RAB10, thus accelerating HCC progression.
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