Acute Decompensated Aortic Stenosis: State of the Art Review

Aortic stenosis (AS) is a progressive disease that carries a poor prognosis. Patients are managed conservatively until satisfying an indication for transcatheter aortic valve implantation (TAVI) or surgical aortic valve replacement (SAVR) based on AS severity and the presence of symptoms or adverse impact on the myocardium. Up to 1 in 3 TAVIs are performed for patients with acute symptoms of dyspnoea at rest, angina, and/or syncope - termed acute decompensated aortic stenosis (ADAS) and require urgent aortic valve replacement. These patients have longer hospital length of stay, undergo physical deconditioning, have a higher rate of acute kidney injury and mortality compared to stable patients with less severe symptoms. There is an urgent need to prevent ADAS and to deliver pathways to manage and improve ADAS-related outcomes. We provide here a contemporary review on epidemiological and pathophysiological aspects of ADAS, with a focus on the impact of ADAS from clinical and economic perspectives. We will offer also a global overview of the available evidence for treatment of ADAS and with priorities suggested for addressing current gaps in the literature and unmet clinical needs to improve outcomes for AS patients. Acute decompensated aortic stenosis (ADAS) is characterised by the acute onset or deterioration of symptoms related to aortic stenosis. It is common and impacts mortality, morbidity and healthcare provision. Several clinical factors can predict ADAS, whilst several others are prognostically important. Screening for AS, optimising timing to aortic valve replacement for AS and expediting treatment once decompensated may improve outcomes. Vector image were obtained from vecteezy.com