GLP-1–Mediated Targeting of Inflammation Corrects Obesogenic Memory in Male Mice

ARTICLE HIGHLIGHTS: Weight loss defense mechanisms and inflammation challenge metabolic disease management, with few treatments available. We developed a mouse model of obesogenic memory and investigated the efficacy of a glucagon-like peptide 1/dexamethasone (GLP-1/Dexa) conjugate that safely and cell-selectively targets inflammation in GLP-1 receptor cells. GLP-1/Dexa offers a promising strategy to correct obesogenic memory and adipose tissue inflammation in male mice. CCR2 monocytes contribute to glucose intolerance associated with obesogenic memory and may be targeted by GLP-1/Dexa.