Role of c‐Fos in DNA damage repair

Abstract c‐Fos, a member of the immediate early gene, serves as a widely used marker of neuronal activation induced by various types of brain damage. In addition, c‐Fos is believed to play a regulatory role in DNA damage repair. This paper reviews the literature on c‐Fos' involvement in the regulation of DNA damage repair and indicates that genes of the Fos family can be induced by various forms of DNA damage. In addition, cells lacking c‐Fos have difficulties in DNA repair. c‐Fos is involved in tumorigenesis and progression as a proto‐oncogene that maintains cancer cell survival, which may also be related to DNA repair. c‐Fos may impact the repair of DNA damage by regulating the expression of downstream proteins, including ATR, ERCC1, XPF, and others. Nonetheless, the underlying mechanisms necessitate further exploration.