Capillary Plasma Separation Microsampling Devices: A Solution for Dried Blood Spot Limitations in Clinical Testing

BioanalysisAhead of Print EditorialCapillary plasma separation microsampling devices: a solution for dried blood spot limitations in clinical testingAmanda Pacheco Bondan & Rafael LindenAmanda Pacheco Bondan https://orcid.org/0009-0008-2004-9545Laboratory of Analytical Toxicology, Universidade Feevale, Rua Rubem Berta, No. 200, CEP 93525-080, Novo Hamburgo, BrazilSearch for more papers by this author & Rafael Linden *Author for correspondence: E-mail Address: rafael.linden@feevale.brhttps://orcid.org/0000-0002-6966-5073Laboratory of Analytical Toxicology, Universidade Feevale, Rua Rubem Berta, No. 200, CEP 93525-080, Novo Hamburgo, BrazilSearch for more papers by this authorPublished Online:23 Jun 2023https://doi.org/10.4155/bio-2023-0109AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinkedInRedditEmail View articleKeywords: capillary microsamplingclinical chemistrydried blood spotsdried plasmamicrosampling devicestherapeutic drug monitoringReferences1. Antunes MV, Charão MF, Linden R. Dried blood spots analysis with mass spectrometry: potentials and pitfalls in therapeutic drug monitoring. Clin. Biochem. 49(13–14), 1035–1046 (2016).Crossref, Medline, CAS, Google Scholar2. Capiau S, Veenhof H, Koster RA et al. Official International Association for Therapeutic Drug Monitoring and Clinical Toxicology Guideline: development and validation of dried blood spot-based methods for therapeutic drug monitoring. Ther. Drug Monit. 41(4), 409–430 (2019).Crossref, Medline, CAS, Google Scholar3. Delahaye L, Veenhof H, Koch BCP, Alffenaar JWC, Linden R, Stove C. Alternative sampling devices to collect dried blood microsamples: state-of-the-art. Ther. Drug Monit. 43(3), 310–321 (2021).Crossref, Medline, Google Scholar4. Baillargeon KR, Mace CR. Microsampling tools for collecting, processing, and storing blood at the point-of-care. Bioeng. Transl. Med. 8, e10476 (2023).Crossref, Medline, CAS, Google Scholar5. Rowland M, Emmons GT. Use of dried blood spots in drug development: pharmacokinetic considerations. AAPS J. 12(3), 290–293 (2010).Crossref, Medline, CAS, Google Scholar6. Corso G, Papagni F, Gelzo M et al. Development and validation of an enzymatic method for total cholesterol analysis using whole blood spot. J. Clin. Lab. Anal. 30(5), 517–523 (2016).Crossref, Medline, CAS, Google Scholar7. Kupke IR, Zeugner S, Gottschalk A, Kather B. Differences in lipid and lipoprotein concentrations of capillary and venous blood samples. Clin. Chim. Acta 97(2–3), 279–283 (1979).Crossref, Medline, CAS, Google Scholar8. Crawford ML, Collier BB, Bradley MN, Holland PL, Shuford CM, Grant RP. Empiricism in microsampling: utilizing a novel lateral flow device and intrinsic normalization to provide accurate and precise clinical analysis from a finger stick. Clin. Chem. 66(6), 821–831 (2020).Crossref, Medline, Google Scholar9. Shuford CM, McConnell EW, Dee S, Grant RP. Pre-analytical conditions influencing analysis of folate in dried plasma microsamples. J. Mass Spectrom. Adv. Clin. Lab. 28, 1–8 (2023).Crossref, Medline, CAS, Google Scholar10. Silliman E, Chung EH, Fitzpatrick E et al. Evaluation of at-home serum anti-Müllerian hormone testing: a head-to-head comparison study. Reprod. Biol. Endocrinol. 20(1), 1–11 (2022).Crossref, Medline, Google Scholar11. Kaiser NK, Steers M, Nichols CM, Mellert H, Pestano GA. Design and characterization of a novel blood collection and transportation device for proteomic applications. Diagnostics 10(12), 1032 (2020).Crossref, Medline, CAS, Google Scholar12. Linden G, Charão MF, Linden R. Evaluation of the HealthID PSD microsampling device for the simultaneous determination of cholesterol, high-density lipoprotein, triglycerides, creatinine, and HbA1c in capillary blood. Clin. Biochem. 110597 (2023). https://doi.org/10.1016/j.clinbiochem.2023.110597Crossref, Medline, Google Scholar13. Carmona S, Seiverth B, Magubane D, Hans L, Hoppler M. Separation of plasma from whole blood by use of the cobas plasma separation card: a compelling alternative to dried blood spots for quantification of HIV-1 viral load. J. Clin. Microbiol. 57(4), e01336–18 (2018).Google Scholar14. Kim JH, Woenker T, Adamec J, Regnier FE. Simple, miniaturized blood plasma extraction method. Anal. Chem. 85(23), 11501–11508 (2013).Crossref, Medline, CAS, Google ScholarFiguresReferencesRelatedDetails Ahead of Print STAY CONNECTED Metrics Downloaded 0 times History Received 25 May 2023 Accepted 12 June 2023 Published online 23 June 2023 Information© 2023 Newlands PressKeywordscapillary microsamplingclinical chemistrydried blood spotsdried plasmamicrosampling devicestherapeutic drug monitoringFinancial & competing interests disclosureR Linden has stock ownership in HealthID Lab, which is the manufacturer of the HealthID PSD. R Linden is the recipient of a research scholarship from the National Council for Scientific and Technological Development in Brazil (CNPQ; grant no. 309453/2022–4). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.No writing assistance was utilized in the production of this manuscript.PDF download