维斯坎
基因亚型
蛋白多糖
细胞外基质
选择性拼接
硫酸软骨素
细胞生物学
硫酸软骨蛋白多糖
糖胺聚糖
遗传学
生物
化学
基因
生物化学
作者
Thomas N. Wight,Anthony J. Day,Inkyung Kang,Ingrid A. Harten,Gernot Kaber,Deg Briggs,Kathleen R. Braun,Joan M. Lemire,Michael G. Kinsella,Aleksander Hinek,Mervyn J. Merrilees
出处
期刊:American Journal of Physiology-cell Physiology
[American Physiological Society]
日期:2023-08-01
卷期号:325 (2): C519-C537
标识
DOI:10.1152/ajpcell.00059.2023
摘要
V3 is an isoform of the extracellular matrix (ECM) proteoglycan (PG) versican generated through alternative splicing of the versican gene such that the two major exons coding for sequences in the protein core that support chondroitin sulfate (CS) glycosaminoglycan (GAG) chain attachment are excluded. Thus, versican V3 isoform carries no GAGs. A survey of PubMed reveals only 50 publications specifically on V3 versican, so it is a very understudied member of the versican family, partly because to date there are no antibodies that can distinguish V3 from the CS-carrying isoforms of versican, that is, to facilitate functional and mechanistic studies. However, a number of in vitro and in vivo studies have identified the expression of the V3 transcript during different phases of development and in disease, and selective overexpression of V3 has shown dramatic phenotypic effects in “gain and loss of function” studies in experimental models. Thus, we thought it would be useful and instructive to discuss the discovery, characterization, and the putative biological importance of the enigmatic V3 isoform of versican.
科研通智能强力驱动
Strongly Powered by AbleSci AI