Abstract Current methods for pressure and temperature sensing face issues such as crosstalk, low integration, and difficulty in achieving large‐scale arrays. These problems significantly impact the practical application value of multifunctional biomimetic sensors in intelligent biomimetic robots. Herein, this paper presents a novel multifunctional biomimetic electronic palm system (BEPS) consisting of 16 bimodal decoupling biomimetic electronic skins (e‐skin). By subtly introducing vertical stacking design and in situ photopolymerization and 3D printing technologies‐based fabrication, large‐scale arrays integration with high sensing performances is constructed. Furthermore, a universal decoupling calculation model is developed, achieving crosstalk‐free sensing of temperature and pressure. To demonstrate the practical application value of the proposed biomimetic palm, three implemented demonstration applications in this paper show that the mechanical hand has the ability to detect water temperature and water level, as well as to confirm the softness and shape of grasped objects. The BEPS system combines neural hand contraction reflexes to achieve closed‐loop control and feedback when dealing with hot and cold objects. This progress has enormous potential in enhancing the functionality and adaptability of robotic systems.