材料科学
纳米技术
间充质干细胞
癌症研究
间质细胞
抗体
炎症
再生医学
肺
氧化应激
巨噬细胞
渗透(HVAC)
单克隆抗体
血管生成
细胞外
转染
肾
个性化医疗
细胞生物学
微泡
医学
药理学
翻译(生物学)
急性肾损伤
精密医学
组织工程
胞外囊泡
细胞外基质
作者
Jiyuan Wu,Xi Liu,Tenghui Ye,Xianghua Zhong,Qin Fu,Zhenzhen Wang,Peng Shi
标识
DOI:10.1021/acsami.5c11126
摘要
Nanovesicles (NVs) have recently gained increasing attention in biomedical applications as alternatives to extracellular vesicles. However, their clinical translation is hindered by limited targeting specificity toward diseased tissues. In this study, we present a DNA-mediated self-assembly strategy to construct multivalent antibody-modified nanovesicles (Multi-NVs) for enhanced targeted delivery. Our results demonstrated that Multi-NVs prepared from mesenchymal stromal cells exhibited robust and specific targeting capabilities, improved cellular uptake efficiency, and promoted endothelial angiogenic activity. Importantly, this modular strategy demonstrated broad applicability across multiple disease models, including acute lung injury (ALI) and acute kidney injury, where Multi-NVs achieved markedly improved tissue targeting. Therapeutically, Multi-NV treatment significantly reduced macrophage infiltration and alleviated lung tissue damage and oxidative stress in ALI, highlighting their potential for precision medicine and personalized therapeutic interventions.
科研通智能强力驱动
Strongly Powered by AbleSci AI