剪接体
RNA剪接
内含子
小剪接体
生物
细胞生物学
多嘧啶束
信使核糖核酸
核糖核酸
小核RNA
ATP酶
前体mRNA
遗传学
生物化学
基因
非编码RNA
酶
作者
Rogério Alves de Almeida,Raymond T. O’Keefe
出处
期刊:RNA Biology
[Informa]
日期:2015-02-01
卷期号:12 (2): 109-114
被引量:14
标识
DOI:10.1080/15476286.2015.1008926
摘要
Pre-mRNA splicing is an essential step in gene expression that removes intron sequences efficiently and accurately to produce a mature mRNA for translation. It is the large and dynamic RNA-protein complex called the spliceosome that catalyzes intron removal. To carry out splicing the spliceosome not only needs to assemble correctly with the pre-mRNA but the spliceosome requires extensive remodelling of its RNA and protein components to execute the 2 steps of intron removal. Spliceosome remodelling is achieved through the action of ATPases that target both RNA and proteins to produce spliceosome conformations competent for each step of spliceosome activation, catalysis and disassembly. An increasing amount of research has pointed to the spliceosome associated NineTeen Complex (NTC) of proteins as targets for the action of a number of the spliceosomal ATPases during spliceosome remodelling. In this point-of-view article we present the latest findings on the changes in the NTC that occur following ATPase action that are required for spliceosome activation, catalysis and disassembly. We proposed that the NTC is one of the main targets of ATPase action during spliceosome remodelling required for pre-mRNA splicing.
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