脂质体
体内
核酸
寡核苷酸
阳离子脂质体
体内分布
药物输送
阳离子聚合
体外
化学
药理学
生物化学
生物
纳米技术
材料科学
DNA
遗传增强
生物技术
有机化学
基因
标识
DOI:10.3109/08982109709035481
摘要
Much attention has focused on cationic liposomes for delivery of antisense oligonucleotides. While these reagents demonstrate efficient delivery and potentiation of antisense oligonucleotides in vitro under serum-free conditions, then-use in vivo may be limited. This report highlights issues including serum-instability, biodistribution, and target-nonspecificity that may hinder their use for efficient nucleic acid delivery in vivo. Given the many advantages of liposomes for drug delivery, alternative liposome formulations of nucleic acid are discussed.
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