细胞毒性
体外
化学
药品
纳米技术
材料科学
化学工程
药理学
生物化学
医学
工程类
作者
Yuanyuan Cai,Guoxin Wu,Deqiang Chu,Liyun Liu,Jian Sun,Meifang Wang,Xiang-Zi Li
标识
DOI:10.1016/j.matchemphys.2022.126348
摘要
[email protected] magnetic nanotubes surrounded by a carbon shell with thick of 10 nm were constructed using nickel nanotubes as core by glucose-solvothermal-method. The morphology, structure, composition, magnetic property, drug release behavior, in-vitro cytotoxicity and antitumor efficacy of the as-prepared [email protected] nanotubes were studied by scanning electron microscopy, transmission electron microscopy, X-ray diffraction, Raman spectrum, energy dispersive X-ray spectroscopy, Fourier transform infrared spectroscopy, vibrating-sample magnetometer, UV–vis spectroscopy, CCK-8 assays and flow cytometry. The results indicated that the as-prepared [email protected] nanotubes had typical hollow core-shell structure, good magnetic property, pH-responsive drug-release functionality and better antitumor activity, compared with nickel nanotubes. It presented low in-vitro cytotoxicity originated in cell apoptosis by S-phase arrest, which made the magnetic [email protected] nanotubes potentially application in biomedicine.
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