GPX4
细胞凋亡
活性氧
非金属
材料科学
程序性细胞死亡
过氧化氢
癌细胞
癌症研究
纳米技术
癌症
谷胱甘肽
生物化学
谷胱甘肽过氧化物酶
生物
酶
金属
遗传学
冶金
作者
Chaohui Zhang,Lin Chen,Qiang Bai,Lina Wang,Siheng Li,Ning Sui,Dongqin Yang,Zhiling Zhu
标识
DOI:10.1021/acsami.2c06721
摘要
Ferroptosis-apoptosis, a new modality of induced cell death dependent on reactive oxygen species, has drawn tremendous attention in the field of nanomedicine. A metal-free ferroptosis-apoptosis inducer was reported based on boron and nitrogen codoped graphdiyne (BN-GDY) that possesses efficient glutathione (GSH) depletion capability and concurrently induces ferroptosis by deactivation of GSH-dependent peroxidases 4 (GPX4) and apoptosis by downregulation of Bcl2. The high catalytic activity of BN-GDY is explicated by both kinetic experiments and density functional theory (DFT) calculations of Gibbs free energy change during hydrogen peroxide (H2O2) decomposition. In addition, a unique sequence Bi-Bi mechanism is discovered, which is distinct from the commonly reported ping-pong Bi-Bi mechanism of most peroxidase mimics and natural enzymes. We anticipate that this nonmetal ferroptosis-apoptosis therapeutic concept by carbon-based nanomaterials would provide proof-of-concept evidence for nanocatalytic medicines in cancer therapy.
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