High efficiency biomimetic electrospun fibers for use in regenerative medicine and drug delivery: A review

Regenerative medicine is a very promising field for the reconstruction of diseased or defective tissues. Biocompatible materials play an important role in making the synthetic extracellular matrix (ECM) environments as three-dimensional (3D) scaffolds for tissue regeneration. These scaffolds should be able to imitate some aspects of the extracellular matrix. Therefore, electrospun-based fibers that can mimic the main elements of the natural matrix are an inspired strategy for restoring tissue response. Nanofibers are effectively helpful for various medical, tissue engineering, and drug delivery applications due to their high surface area. In this regard, to achieve greater efficiency of nanofibers, their surface is functionalized with different strategies to continuously release various factors in drug delivery and increase cellular response in tissue engineering. This paper contains a comprehensive overview of the application of biomimetic electrospun nanofibers in tissue engineering and drug delivery. The article also focuses on the production, benefits, and applications of various biomimetic fibers that can be used in tissue engineering and drug delivery. In addition, the different techniques used to modify the surface of nanofibers in tissue engineering and drug delivery are briefly discussed.