线粒体DNA
怀孕
免疫系统
炎症
生物
细胞
线粒体
先天免疫系统
受体
程序性细胞死亡
免疫学
细胞生物学
DNA
作者
Jessica L. Bradshaw,Spencer C Cushen,Nicole R Phillips,Styliani Goulopoulou
出处
期刊:Physiology
[American Physiological Society]
日期:2022-01-10
被引量:1
标识
DOI:10.1152/physiol.00037.2021
摘要
Circulating cell-free mitochondrial DNA (ccf-mtDNA) released upon cell injury or death stimulates diverse pattern recognition receptors to activate innate immune responses and initiate systemic inflammation. In this review, we discuss the temporal changes of ccf-mtDNA during pregnancy and its potential contribution to adverse pregnancy outcomes in pregnancy complications.
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