活性氧
白色念珠菌
过氧化氢酶
超氧化物歧化酶
氧化应激
白色体
谷胱甘肽过氧化物酶
药理学
化学
抗氧化剂
微生物学
NADPH氧化酶
谷胱甘肽
生物
酶
生物化学
作者
Lei Chen,Fei Wang,Su Qu,Xiaona He,Yongxin Zhang,Yi Zhou,Ke Yang,Yongxin Li,Man Liu,Xue Peng,Jianhua Tian
出处
期刊:Antioxidants
[MDPI AG]
日期:2022-01-18
卷期号:11 (2): 178-178
被引量:5
标识
DOI:10.3390/antiox11020178
摘要
Vulvovaginal candidiasis (VVC) is one of the most frequent diseases induced by Candida albicans (C. albicans) during pregnancy, which results in enormous pain to women and their partners in daily life. Perillaldehyde (PAE), a natural monoterpenoid, has significant anti-microbial, anti-inflammatory and anti-oxidation effects. Reactive oxygen species (ROS) are key factors for the host to resist the invasion of fungi. However, excess ROS can cause additional damage independent of the pathogen itself, and the mechanism of ROS in VVC has not been investigated. In this murine study, we revealed that C. albicans infection increased the expression of NADPH oxidase 2 (NOX2) and the content of malonaldehyde (MDA). C. albicans inhibited the activity of antioxidant enzymes in the vagina, including superoxide dismutase (SOD), Catalase (CAT), glutathione peroxidase (GSH-PX) and heme oxygenase (HO-1), which were returned to normal levels after treatment with PAE. Furthermore, PAE inhibited the activities of Keap1 and promoted Nrf2 transfer from cytoplasm to nucleus, which were mediated by excessive accumulation of ROS in the VVC mice. In this study, we also indicated that PAE inhibited the apoptosis of vagina cells via Caspase 9- Caspase 7-PARP pathway and prevented the release of IL-1ꞵ in VVC mice. In summary, this study revealed that the treatment of VVC in mice with PAE might be mediated by inhibition of ROS, and established the therapeutic potential of PAE as an antifungal agent for the treatment of VVC.
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