疾病
心房颤动
医学
心力衰竭
生物年龄
心脏病
人口老龄化
风险因素
老化
人口
重症监护医学
内科学
心脏病学
老年学
环境卫生
作者
Marja Steenman,Gilles Lande
出处
期刊:Biophysical Reviews
[Springer International Publishing]
日期:2017-03-20
卷期号:9 (2): 131-137
被引量:207
标识
DOI:10.1007/s12551-017-0255-9
摘要
The world population continues to grow older rapidly, mostly because of declining fertility and increasing longevity. Since age represents the largest risk factor for cardiovascular disease, the prevalence of these pathologies increases dramatically with increasing age. In order to improve patient care and prevention for age-related cardiac diseases, insight should be gained from the analysis of processes involved in and leading to cardiac aging. It is from this perspective that we provide here an overview of changes associated with age in the heart on four levels: functional, structural, cellular and molecular. We highlight those changes that are in common with the development of the two major age-associated cardiac pathologies: heart failure and atrial fibrillation. These commonly affected processes in aging and cardiac pathophysiology may provide an explanation for the age risk factor in cardiac disease.
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