纳米载体
化学
体内
甘露醇
药品
胶束
药物输送
组合化学
劈理(地质)
食品药品监督管理局
体外
计算机科学
药理学
有机化学
生物化学
水溶液
医学
材料科学
生物
生物技术
复合材料
断裂(地质)
作者
Yuanpei Li,Wenwu Xiao,Kai Xiao,Lorenzo Berti,Juntao Luo,Harry Tseng,Gabriel Pui Cheong Fung,Kit S. Lam
标识
DOI:10.1002/anie.201107144
摘要
Demand and deliver: Micelles reversibly crosslinked by boronate esters (see scheme) show in vitro and in vivo stability, and thus minimize premature drug release under physiological conditions. After reaching the tumor sites, drug (stars in scheme) release is activated by cleavage of the boronate esters by the acidic conditions around the tumor or in the target cells, or by the administration of mannitol. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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