ABSTRACT About 341 (average age of 38.0 ± 2.5 years) patients with periodontal disease were included in this study. All the patients were not treated for periodontal disease for a period of 6 months prior to this study. All the patients were not on any hormonal therapy. Antibodies to Porphyromonas gingivalis (P. gingivalis) were determined in blood serum by enzyme-linked immunosorbent assay (ELISA) method. Findings from this study suggest immune response to P. gingivalis is more effective in males than in females. Smoking and obesity tends to reduce effective immune response. How to cite this article Tebloeva LM, Revazova ZE, Fabrikant KG, Dmitrieva LA, Gurevich KG. Differences in Immune Response to Porphyromonas gingivalis. J Contemp Dent Pract 2014;15(5):573-575.