生物
转录因子
生长因子
HT1080型
基因敲除
癌细胞
细胞生长
细胞生物学
癌症研究
分子生物学
细胞
细胞培养
癌症
基因
遗传学
受体
作者
Yuhki Tada,Yukari Yamaguchi,Tomoaki Kinjo,Xiahong Song,Tadayuki Akagi,Hiroyuki Takamura,Tetsuo Ohta,Takashi Yokota,Hiroshi Koide
出处
期刊:Oncogene
[Springer Nature]
日期:2014-01-27
卷期号:34 (6): 752-760
被引量:30
摘要
Several common biological properties between cancer cells and embryonic stem (ES) cells suggest the possibility that some genes expressed in ES cells might have important roles in cancer cell growth. The transcription factor ZFP57 is expressed in self-renewing ES cells and its expression level decreases during ES cell differentiation. This study showed that ZFP57 is involved in the anchorage-independent growth of human fibrosarcoma HT1080 cells in soft agar. ZFP57 overexpression enhanced, whereas knockdown suppressed, HT1080 tumor formation in nude mice. Furthermore, ZFP57 regulates the expression of insulin-like growth factor 2 (IGF2), which has a critical role in ZFP57-induced anchorage-independent growth. ZFP57 also promotes anchorage-independent growth in ES cells and immortal fibroblasts. Finally, immunohistochemical analysis revealed that ZFP57 is overexpressed in human cancer clinical specimens. Taken together, these results suggest that the ES-specific transcription factor ZFP57 is a novel oncogene.
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