Spectral Data Analyses and Structure Elucidation of Hypoglycemic Drug Glipizide

Abstract The infrared spectrum, ultraviolet spectrum, mass spectrum, and nuclear magnetic resonance spectrum of glipizide, a blood-glucose-lowering drug, were reported and interpreted comprehensively. All the 1H and 13C NMR chemical shifts were assigned by means of distoritionless enhancement by polarization transfer-135, 1H-1H and 13C-1H correlation spectroscopy, and correlation spectroscopy via long range coupling. The main characteristic fragmentations, in electron impact and electrospray ionization mass spectra, vibrations of functional groups in infrared spectrum, and electron transition in ultraviolet spectrum of glipizide were also discussed in detail.