肠内分泌细胞
新颖性
激励显著性
食物摄入量
认知
神经科学
生物
内分泌系统
多巴胺
能量稳态
内分泌学
心理学
内科学
激素
医学
社会心理学
肥胖
作者
Ulrike Stadlbauer,Stephen C. Woods,Wolfgang Langhans,Urs Meyer
标识
DOI:10.1016/j.yfrne.2014.12.003
摘要
The gastrointestinal hormone peptide tyrosine tyrosine 3–36 (PYY3–36) has attained broad recognition with respect to its involvement in energy homeostasis and the control of food intake. It is mainly secreted by distal intestinal enteroendocrine L-cells in response to eating and exerts neurally mediated, paracrine and endocrine effects on various target organs. In addition to its gastrointestinal effects, PYY3–36 has long been known to inhibit food intake. Recent closer examination of the effects of PYY3–36 revealed that this gut-derived peptide also influences a wide spectrum of behavioral and cognitive functions that are pivotal for basic processes of perception and judgment, including central information processing, salience learning, working memory, and behavioral responding to novelty. Here, we review the effects of PYY3–36 that go beyond food intake and provide a conceptual framework suggesting that several apparently unrelated behavioral actions of PYY3–36 may actually reflect different manifestations of modulating the central dopamine system.
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