医学
炎症
肺动脉高压
免疫
发病机制
免疫系统
免疫学
疾病
趋化因子
内科学
病理
作者
Marlene Rabinovitch,Christophe Guignabert,Marc Humbert,Mark R. Nicolls
出处
期刊:Circulation Research
[Ovid Technologies (Wolters Kluwer)]
日期:2014-06-20
卷期号:115 (1): 165-175
被引量:672
标识
DOI:10.1161/circresaha.113.301141
摘要
This review summarizes an expanding body of knowledge indicating that failure to resolve inflammation and altered immune processes underlie the development of pulmonary arterial hypertension. The chemokines and cytokines implicated in pulmonary arterial hypertension that could form a biomarker platform are discussed. Pre-clinical studies that provide the basis for dysregulated immunity in animal models of the disease are reviewed. In addition, we present therapies that target inflammatory/immune mechanisms that are currently enrolling patients, and discuss others in development. We show how genetic and metabolic abnormalities are inextricably linked to dysregulated immunity and adverse remodeling in the pulmonary arteries.
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