化学
立体中心
酮
催化作用
对映选择合成
芳基
反应性(心理学)
产量(工程)
配体(生物化学)
药物化学
烷基
有机化学
基础(拓扑)
医学
数学分析
生物化学
替代医学
材料科学
受体
数学
病理
冶金
作者
Takayuki Hamada,A. Chieffi,Jens Åhman,Stephen L. Buchwald
摘要
A new catalyst system for the enantioselective alpha-arylation of ketones is reported. This catalyst, prepared from Pd(2)(dba)(3) and a bulky dialkylphosphino-binaphthyl ligand, is able to effect the asymmetric arylation of ketone enolates with aryl bromides utilizing NaO(t)()Bu as base. These new catalysts enjoy much higher reactivity than previous systems; arylation reactions could be effected at room temperature with only 2 mol % of the Pd catalyst. The coupling of alpha-alkyl-alpha'-protected cyclopentanones proceeded in high yield, and the resulting quaternary stereogenic center was installed in up to 94% ee.
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