地氯酸
前鼻孔
金黄色葡萄球菌
殖民地化
微生物学
医学
人口
葡萄球菌感染
生物
微球菌科
葡萄球菌
免疫学
耐甲氧西林金黄色葡萄球菌
细菌
遗传学
环境卫生
作者
Christopher Weidenmaier,John F. Kokai‐Kun,Sascha A. Kristian,Tanya Chanturiya,Hubert Kalbacher,Matthias Gross,Graeme Nicholson,Birgid Neumeister,James J. Mond,Andreas Peschel
出处
期刊:Nature Medicine
[Springer Nature]
日期:2004-02-01
卷期号:10 (3): 243-245
被引量:516
摘要
Colonization of the anterior nares in approximately 37% of the population is a major risk factor for severe Staphylococcus aureus infections. Here we show that wall teichoic acid (WTA), a surface-exposed staphylococcal polymer, is essential for nasal colonization and mediates interaction with human nasal epithelial cells. WTA-deficient mutants were impaired in their adherence to nasal cells, and were completely unable to colonize cotton rat nares. This study describes the first essential factor for S. aureus nasal colonization.
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