环磷酰胺
微生物学
生物
失调
MTT法
石斛
体外
肠道菌群
免疫学
生物化学
化疗
遗传学
植物
作者
Wei Liu,Ran Yan,Liang Zhang
标识
DOI:10.1016/s1875-5364(19)30062-7
摘要
To recognize the potential medicinal value of the Dendrobium sonia, polysaccharide (DSP) was extracted, purified, and investigated for its immunomodulatory activity. In vitro, DSP was shown to enhance the viability (MTT assay) and phagocytosis of macrophages. In cyclophosphamide-induced immunosuppressed mice, DSP increased serum levels of TNF-α, IL-6 and IFN-γ (enzyme-linked immunosorbent assay, ELISA), and ameliorated the imbalance of the community of gut microbiota as detected by 16S ribosomal RNA gene sequencing. These results suggest that DSP might be beneficial for patients under immunosuppressed conditions.
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