化学
羟基化
代谢物
代谢物分析
葡萄糖醛酸
体内
尿
药理学
色谱法
质谱法
四极飞行时间
代谢途径
乙酰化
代谢组
代谢组学
串联质谱法
新陈代谢
生物化学
医学
生物
酶
生物技术
基因
作者
Tong Wang,Xinchi Feng,Lei Ding,Kun Wang,Xu-Liu Shi,Liwei Chai,Yang Li,Feng Qiu
标识
DOI:10.1016/j.chmed.2019.03.008
摘要
To identify the in vivo metabolites of icaritin and speculate its metabolic profiling in rats. The plasma, bile, urine, and feces of rats were collected after orally administration of icaritin at a dose of 100 mg/kg and detected by an ultra-high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC/Q-TOF-MS/MS) in both positive and negative modes. The data of treated and control groups were compared and analyzed with the aid of Metabolynx XS software. A total of 25 metabolites were identified in the biosamples, and 14 of them were reported for the first time to our knowledge. The main metabolite types of icaritin in rats were glucuronide conjugation, methylation, hydroxylation, reduction, and acetylation.
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