已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Neutrophilic Dermatoses and Their Implication in Pathophysiology of Asthma and Other Respiratory Comorbidities: A Narrative Review

医学 背景(考古学) 疾病 免疫学 促炎细胞因子 病理生理学 病理 皮肤病科 炎症 生物 古生物学
作者
Islam Elbayoumi Salem,Mark Kimak,Rosalynn R.Z. Conic,Nicola Luigi Bragazzi,Abdulla Watad,Mohammad Adawi,Charlie Bridgewood,Alessia Pacifico,Pierachille Santus,Maurizio Rizzi,Stephen Petrou,Delia Colombo,Marco Fiore,P. D. Pigatto,Giovanni Damiani
出处
期刊:BioMed Research International [Hindawi Limited]
卷期号:2019: 1-17 被引量:6
标识
DOI:10.1155/2019/7315274
摘要

Neutrophilic dermatoses (ND) are a polymorphous group of noncontagious dermatological disorders that share the common histological feature of a sterile cutaneous infiltration of mature neutrophils. Clinical manifestations can vary from nodules, pustules, and bulla to erosions and ulcerations. The etiopathogenesis of neutrophilic dermatoses has continuously evolved. Accumulating genetic, clinical, and histological evidence point to NDs being classified in the spectrum of autoinflammatory conditions. However, unlike the monogenic autoinflammatory syndromes where a clear multiple change in the inflammasome structure/function is demonstrated, NDs display several proinflammatory abnormalities, mainly driven by IL-1, IL-17, and tumor necrosis factor-alpha (TNF-a). Additionally, because of the frequent association with extracutaneous manifestations where neutrophils seem to play a crucial role, it was plausible also to consider NDs as a cutaneous presentation of a systemic neutrophilic condition. Neutrophilic dermatoses are more frequently recognized in association with respiratory disorders than by chance alone. The combination of the two, particularly in the context of their overlapping immune responses mediated primarily by neutrophils, raises the likelihood of a common neutrophilic systemic disease or an aberrant innate immunity disorder. Associated respiratory conditions can serve as a trigger or may develop or be exacerbated secondary to the uncontrolled skin disorder. Physicians should be aware of the possible pulmonary comorbidities and apply this knowledge in the three steps of patients’ management, work-up, diagnosis, and treatment. In this review, we attempt to unravel the pathophysiological mechanisms of this association and also present some evidence for the role of targeted therapy in the treatment of both conditions.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
清爽牛排完成签到,获得积分10
2秒前
华仔应助12345采纳,获得10
3秒前
4秒前
4秒前
5秒前
帅气天荷完成签到 ,获得积分10
5秒前
柳墨白发布了新的文献求助10
6秒前
IrisMessi完成签到,获得积分10
6秒前
蓝天下载完成签到,获得积分10
7秒前
Hayat发布了新的文献求助20
8秒前
清爽牛排发布了新的文献求助10
8秒前
18秒前
22秒前
23秒前
ddd完成签到,获得积分10
23秒前
科里斯皮尔应助ybheart采纳,获得10
24秒前
25秒前
852应助Ying采纳,获得10
25秒前
开放冰香发布了新的文献求助10
25秒前
何博发布了新的文献求助10
27秒前
12345发布了新的文献求助10
29秒前
????完成签到,获得积分10
30秒前
上官若男应助爆炸小耘采纳,获得10
33秒前
小不点给小不点的求助进行了留言
34秒前
43秒前
小二郎应助小白采纳,获得10
43秒前
44秒前
Wellbeing完成签到,获得积分10
45秒前
47秒前
amber发布了新的文献求助10
47秒前
无私的鲂发布了新的文献求助10
48秒前
Hello应助向绝山采纳,获得10
48秒前
佟宛海发布了新的文献求助10
49秒前
winnie_ymq完成签到 ,获得积分10
50秒前
草拟大坝应助ybheart采纳,获得10
50秒前
51秒前
misalia完成签到 ,获得积分10
53秒前
54秒前
田様应助amber采纳,获得10
55秒前
56秒前
高分求助中
Teaching Social and Emotional Learning in Physical Education 900
Plesiosaur extinction cycles; events that mark the beginning, middle and end of the Cretaceous 800
Chinese-English Translation Lexicon Version 3.0 500
Recherches Ethnographiques sue les Yao dans la Chine du Sud 500
Two-sample Mendelian randomization analysis reveals causal relationships between blood lipids and venous thromboembolism 500
[Lambert-Eaton syndrome without calcium channel autoantibodies] 460
Aspect and Predication: The Semantics of Argument Structure 400
热门求助领域 (近24小时)
化学 材料科学 医学 生物 有机化学 工程类 生物化学 纳米技术 物理 内科学 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 电极 光电子学 量子力学
热门帖子
关注 科研通微信公众号,转发送积分 2394950
求助须知:如何正确求助?哪些是违规求助? 2098359
关于积分的说明 5288378
捐赠科研通 1825897
什么是DOI,文献DOI怎么找? 910323
版权声明 559972
科研通“疑难数据库(出版商)”最低求助积分说明 486547