With the developing of microbial degradation technology,more and more achievements have been applied to poly-containing wastewater treatment with unique advantage and tremendous potential.In this paper,advantages and mechanisms of microbial degradation of polyacrylamide are introduced,influential factors of microbial degradation of polyacrylamide are discussed,the research progress of microbial degradation at home and abroad are reviewed,the deficiencies in the practical application of microbial degradation are summarized.