女儿
多发性骨髓瘤
入射(几何)
人口
家庭聚集
医学
儿科
遗传学
人口学
生物
免疫学
进化生物学
环境卫生
社会学
光学
物理
作者
P Crozes-Bony,E Palazzo,Otto Meyer,De Bandt M,Kahn Mf
出处
期刊:PubMed
日期:1995-06-01
卷期号:62 (6): 439-45
被引量:3
摘要
We report a case of familial multiple myeloma in a father and daughter. The same lambda chain was detectable in both patients. Symptom onset occurred three years earlier in the daughter than in the father. We found 52 previously published cases of familial myeloma, of which only 13 occurred in a parent and child. Given the incidence of myeloma in the general population, the occurrence of several cases in the same family is probably not due to chance. The few available data on karyotypes and oncogenes are discordant. The respective role of genetic factors and environmental factors is discussed.
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