Arsenic Dispensing Powder Promotes Erythropoiesis in Myelodysplastic Syndromes via Downregulation of HIF1A and Upregulation of GATA Factors

骨髓增生异常综合症 癌症研究 红细胞生成 下调和上调 无效红细胞生成 医学 贫血 骨髓 内科学 生物 生物化学 基因
作者
Teng Fan,Xiaomin Feng,Asumi Yokota,Weiyi Liu,Yuting Tang,Xiaomei Yan,Haiyan Xiao,Yue Wang,Zhongyang Deng,Pan Zhao,Mingjing Wang,Hongzhi Wang,Rou Ma,Xiaomei Hu,Gang Huang
出处
期刊:The American Journal of Chinese Medicine [World Scientific]
卷期号:49 (02): 461-485 被引量:5
标识
DOI:10.1142/s0192415x2150021x
摘要

Traditional Chinese Medicine (TCM) is a practical medicine based on thousands of years of medical practice in China. Arsenic dispensing powder (ADP) has been used as a treatment for MDS patients with a superior efficacy on anemia at Xiyuan Hospital of China Academy of Chinese Medical Sciences. In this study, we retrospectively analyzed MDS patients that received ADP treatment in the past 9 years and confirmed that ADP improves patients’ anemia and prolongs overall survival in intermediate-risk MDS patients. Then, we used the MDS transgenic mice model and cell line to explore the drug mechanism. In normal and MDS cells, ADP does not show cellular toxicity but promotes differentiation. In mouse MDS models, we observed that ADP showed significant efficacy on promoting erythropoiesis. In the BFU-E and CFU-E assays, ADP could promote erythropoiesis not only in normal clones but also in MDS clones. Mechanistically, we found that ADP could downregulate HIF1A in MDS clones through upregulation of VHL, P53 and MDM2, which is involved in two parallel pathways to downregulate HIF1A. We also confirmed that ADP upregulates GATA factors in normal clones. Thus, our clinical and experimental studies indicate that ADP is a promising drug to promote erythropoiesis in both MDS and normal clones with a superior outcome than current regular therapies. ADP promotes erythropoiesis in myelodysplastic syndromes via downregulation of HIF1A and upregulation of GATA factors.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Hello应助Arbor采纳,获得10
1秒前
yize发布了新的文献求助10
2秒前
2秒前
2秒前
义气胡萝卜关注了科研通微信公众号
3秒前
大个应助向日葵采纳,获得10
3秒前
xiangbo发布了新的文献求助10
3秒前
3秒前
跳跃觅夏发布了新的文献求助10
4秒前
4秒前
4秒前
且泛轻舟发布了新的文献求助10
4秒前
5秒前
笑点低薯片完成签到,获得积分10
5秒前
搜集达人应助pine采纳,获得10
5秒前
wure10发布了新的文献求助20
5秒前
6秒前
6秒前
李爱国应助jingdaitianxiang采纳,获得10
6秒前
上官若男应助Qianwen采纳,获得10
6秒前
林林发布了新的文献求助10
7秒前
7秒前
7秒前
FashionBoy应助zz采纳,获得10
7秒前
科研通AI5应助勇哥你好采纳,获得10
8秒前
超级板凳完成签到,获得积分20
8秒前
9秒前
充电宝应助youyuguang采纳,获得10
10秒前
七八九完成签到 ,获得积分10
10秒前
10秒前
轻松旭尧完成签到,获得积分10
10秒前
11秒前
XIN发布了新的文献求助10
11秒前
在水一方应助忧郁静丹采纳,获得10
11秒前
豆包糊了发布了新的文献求助10
12秒前
cici发布了新的文献求助10
13秒前
13秒前
13秒前
快乐难敌发布了新的文献求助10
14秒前
1111应助安静的遥采纳,获得10
14秒前
高分求助中
【重要!!请各位用户详细阅读此贴】科研通的精品贴汇总(请勿应助) 10000
Quantitative Perfusion MRI Techniques, Applications and Practical Considerations 2000
Genomic signature of non-random mating in human complex traits 2000
Semantics for Latin: An Introduction 1099
醤油醸造の最新の技術と研究 1000
Plutonium Handbook 1000
Three plays : drama 1000
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4109160
求助须知:如何正确求助?哪些是违规求助? 3647461
关于积分的说明 11553683
捐赠科研通 3353426
什么是DOI,文献DOI怎么找? 1842337
邀请新用户注册赠送积分活动 908597
科研通“疑难数据库(出版商)”最低求助积分说明 825644