败血症
医学
多发性硬化
免疫系统
免疫学
免疫失调
细胞激素风暴
自身免疫
细胞因子
疾病
内科学
传染病(医学专业)
2019年冠状病毒病(COVID-19)
作者
Djordje Miljković,Suzana Stanisavljević,Isaac J. Jensen,Thomas S. Griffith,Vladimir P. Badovinac
标识
DOI:10.1016/j.imlet.2021.07.008
摘要
Sepsis is a life-threatening condition characterized by an acute cytokine storm followed by prolonged dysfunction of the immune system in the survivors. Post-septic lymphopenia and functional deficits of the remaining immune cells lead to increased susceptibility to secondary infections and other morbid conditions causing late death in the patients. This state of post-septic immunoparalysis may also influence disorders stemming from inappropriate or overactive immune responses, such as autoimmune and immunoinflammatory diseases, including multiple sclerosis. In addition, ongoing autoimmunity likely influences the susceptibility to and outcome of sepsis. This review article addresses the bidirectional relationship between sepsis and multiple sclerosis, with a focus on the immunologic mechanisms of the interaction and potential directions for future studies.
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