重症肌无力
医学
机械通风
2019年冠状病毒病(COVID-19)
重症监护室
观察研究
回顾性队列研究
大学医院
儿科
疾病
内科学
传染病(医学专业)
作者
Antonio Edvan Camelo-Filho,Ana M. G. Silva,Eduardo de Paula Estephan,A A Zambon,Rodrigo de Holanda Mendonça,Paulo Henrique Couto Souza,Wladimir Bocca Vieira de Rezende Pinto,Acary Souza Bulle Oliveira,Iron Dangoni-Filho,Ana Flávia Pincerno Pouza,Berenice Co Valerio,Edmar Zanoteli
标识
DOI:10.3389/fneur.2020.01053
摘要
Myasthenia gravis (MG), an autoimmune neuromuscular disorder, may be a risk factor for severe COVID-19. We conducted an observational retrospective study with 15 consecutive adult MG patients admitted with COVID-19 at four hospitals in São Paulo, Brazil. Most patients with MG hospitalized for COVID-19 had severe courses of the disease: 87% were admitted in the intensive care unit, 73% needed mechanical ventilation, and 30% died. Immunoglobulin use and the plasma exchange procedure were safe. Immunosuppressive therapy seems to be associated with better outcomes, as it might play a protective role.
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