药物化学
立体化学
亲核细胞
环加成
区域选择性
废止
作者
Wei-Cheng Yuan,Jian Zuo,Shu-Pei Yuan,Jian-Qiang Zhao,Zhen-Hua Wang,Yong You
出处
期刊:Organic chemistry frontiers
[The Royal Society of Chemistry]
日期:2021-02-23
卷期号:8 (4): 784-791
被引量:1
摘要
A divergent method for ring expansion and ring opening of 3-halooxindoles has been developed. Under mild base-mediated conditions, 3-halooxindoles generate indolones in situ, which then react smoothly with N-alkoxycarbonyl-O-tosylhydroxylamines to give 4-aminoquinolin-2-ones and N-Cbz-N′-arylureas in good to excellent yields via ring expansion and opening pathways, respectively. This protocol is characterized by easy availability of substrates, user-friendly reaction conditions, broad functional group tolerance, and a simple operation procedure.
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