2型糖尿病
γ蛋白杆菌
肠道菌群
生物
微生物群
普雷沃菌属
粪便
糖尿病
地中海饮食法
生理学
内科学
医学
内分泌学
生物信息学
免疫学
微生物学
16S核糖体RNA
遗传学
细菌
作者
Antonio Camargo,Cristina Vals-Delgado,Juan F. Alcalá‐Díaz,Alejandro Villasanta-González,Francisco Gómez-Delgado,Carmen Haro,Ana León-Acuña,Magdalena P. Cardelo,José D. Torres-Peña,Ipek Guler,Marı́a M. Malagón,José M. Ordovás,Pablo Pérez-Martı́nez,Javier Delgado-Lista,José López‐Miranda
标识
DOI:10.1002/mnfr.202000730
摘要
The differences between the baseline gut microbiota of patients who developed type 2 diabetes (T2D) consuming a low-fat (LF) or a Mediterranean (Med) diet are explored and risk scores are developed to predict the individual risk of developing T2D associated with the consumption of LF or Med diet.All the patients from the CORDIOPREV study without T2D at baseline (n = 462) whose fecal sample are available, are included. Gut microbiota is analyzed by 16S sequencing and the risk of T2D after a median follow-up of 60 months assessed by Cox analysis. Linear discriminant analysis effect size (LEfSe) analysis shows a different baseline gut microbiota in patients who developed T2D consuming LF and Med diets. A higher abundance of Paraprevotella, and lower Gammaproteobacteria and B. uniformis are associated with T2D risk when an LF diet is consumed. In contrast, higher abundances of Saccharibacteria, Betaproteobacteria, and Prevotella are associated with T2D risk when a Med diet is consumed.The results suggest that different interactions between the microbiome and dietary patterns may partially determine the risk of T2D development, which may be used for selecting personalized dietary models to prevent T2D.
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