医学
冠状动脉疾病
内科学
优势比
置信区间
维生素D与神经学
心脏病学
胃肠病学
队列
前瞻性队列研究
CYP24A1型
骨化三醇受体
作者
Monica Verdoia,Claudia Ceccon,Matteo Nardin,Federica Negro,Marco Marcolongo,Giuseppe De Luca
出处
期刊:Blood Coagulation & Fibrinolysis
[Ovid Technologies (Wolters Kluwer)]
日期:2020-06-09
卷期号:31 (6): 366-371
被引量:2
标识
DOI:10.1097/mbc.0000000000000922
摘要
Recent attention has been focused on the regulation of vitamin D metabolism as modulating the cardiovascular benefits of vitamin D. The aim of the current study was to evaluate the functional impact of the genetic polymorphism rs2762939 of CYP24A1, the hydroxylase-enzyme modulating the inactivation of vitamin D, on the prevalence and extent of coronary artery disease (CAD).A consecutive cohort of patients undergoing coronary angiography in a single centre was included. Significant CAD was defined as at least one stenosis more than 50%, severe CAD as left main and/or three-vessel disease. Among 1204 patients, 673 (55.8%) carried the C allele. Baseline features showed a lower use of beta-blockers among the C-carriers ( P = 0.01) and higher levels of C-reactive protein ( P = 0.05). The prevalence of CAD and severe CAD was not conditioned by CYP24A1 genetic status [78.7%-GG vs. 81.2%-C-carriers; P = 0.31; adjusted odds ratio (95% confidence interval ) = 0.71(0.20–2.56), P = 0.60 and 29.1%-GG vs. 29.5%-C carriers P = 0.95; adjusted odds ratio (95% confidence interval) = 0.87 (0.73–1.04), P = 0.13, respectively]. Coronary calcifications were significantly higher among GG homozygotes ( P = 0.005). This study showed that the polymorphisms rs2762939 of CYP24A1 is not associated with the prevalence and extent of CAD. However, the C-allele carriage significantly lowers the rate of coronary calcifications.
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