Exosome therapy in hair regeneration: A literature review of the evidence, challenges, and future opportunities

外体 微泡 医学 脱发 临床试验 再生(生物学) 再生医学 生物信息学 病理 干细胞 皮肤病科 生物 小RNA 细胞生物学 生物化学 基因
作者
Yana Kost,Ahava Muskat,Nour Mhaimeed,Roya Nazarian,Kseniya Kobets
出处
期刊:Journal of Cosmetic Dermatology [Wiley]
卷期号:21 (8): 3226-3231 被引量:10
标识
DOI:10.1111/jocd.15008
摘要

Abstract Background Alopecia is a common chief complaint and is challenging to treat. As such, regenerative treatments to promote hair growth are an emerging area of research. Exosomes, which are extracellular vesicles involved in cell communication, homeostasis, differentiation, and organogenesis, have been shown to play a central role in hair morphogenesis and regeneration with potential for use as alopecia treatment. Aims This review summarizes and assesses the body of literature surrounding exosomes as regenerative therapeutics for alopecia and identifies areas for improvement in future research. Methods A review was conducted using a comprehensive list of keywords including “exosome,” “alopecia,” and “hair loss” on PubMed, EMBASE, and Google Scholar databases published from inception to February 2022. Reference lists of identified articles were included. 47 studies were included. Clinical trial databases were searched using the term “exosome”; however, no trials relevant to hair growth were identified. Results Our updated and comprehensive review details the history of exosome use in medicine, postulated underlying mechanisms in treating hair loss, and current clinical studies. Preclinical studies demonstrate clear benefits of exosome therapeutics in regenerative medicine and for hair loss treatment. Clinical trials demonstrate safety of exosome use in medicine, but data showing efficacy and safety of exosome therapy for alopecia are lacking. We identified several gaps in knowledge required for effective clinical translation including safety, exosome source, and optimal treatment delivery mechanism and dosage. Conclusion Exosomes are on the horizon as an exciting therapeutic for the treatment of alopecia. Further studies and clinical trials are required.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
zz发布了新的文献求助10
2秒前
曼曼发布了新的文献求助10
3秒前
ffnvv发布了新的文献求助10
4秒前
辛勤觅儿发布了新的文献求助10
6秒前
agui完成签到,获得积分10
8秒前
10秒前
15秒前
17秒前
充电宝应助VL_3采纳,获得10
17秒前
17秒前
星辰大海应助Gser采纳,获得10
18秒前
Skywalker发布了新的文献求助30
18秒前
19秒前
19秒前
宣洋发布了新的文献求助10
20秒前
orixero应助宣洋采纳,获得10
24秒前
28秒前
嘿嘿完成签到 ,获得积分10
29秒前
楠木完成签到 ,获得积分10
29秒前
30秒前
Analchem发布了新的文献求助10
33秒前
一番星发布了新的文献求助10
33秒前
明理夏波完成签到 ,获得积分10
33秒前
亓明慧发布了新的文献求助10
36秒前
曼曼完成签到,获得积分10
39秒前
cfy完成签到,获得积分10
40秒前
要不你报警吧完成签到 ,获得积分10
40秒前
桐桐应助pipi采纳,获得10
40秒前
Analchem完成签到,获得积分10
41秒前
Ava应助科研通管家采纳,获得10
41秒前
Jasper应助科研通管家采纳,获得10
42秒前
Orange应助科研通管家采纳,获得10
42秒前
小马甲应助科研通管家采纳,获得10
42秒前
shinysparrow应助科研通管家采纳,获得10
42秒前
搜集达人应助科研通管家采纳,获得10
42秒前
42秒前
Nolan完成签到,获得积分10
44秒前
NexusExplorer应助iyy采纳,获得10
45秒前
46秒前
NexusExplorer应助求助萌新采纳,获得10
47秒前
高分求助中
Teaching Social and Emotional Learning in Physical Education 900
Chinese-English Translation Lexicon Version 3.0 500
[Lambert-Eaton syndrome without calcium channel autoantibodies] 440
Plesiosaur extinction cycles; events that mark the beginning, middle and end of the Cretaceous 400
Two-sample Mendelian randomization analysis reveals causal relationships between blood lipids and venous thromboembolism 400
薩提亞模式團體方案對青年情侶輔導效果之研究 400
3X3 Basketball: Everything You Need to Know 310
热门求助领域 (近24小时)
化学 材料科学 医学 生物 有机化学 工程类 生物化学 纳米技术 物理 内科学 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 电极 光电子学 量子力学
热门帖子
关注 科研通微信公众号,转发送积分 2386515
求助须知:如何正确求助?哪些是违规求助? 2092963
关于积分的说明 5266585
捐赠科研通 1819823
什么是DOI,文献DOI怎么找? 907766
版权声明 559181
科研通“疑难数据库(出版商)”最低求助积分说明 484897