氧化三甲胺
医学
心力衰竭
胆碱
肠道菌群
内科学
肉碱
指南
病理生理学
代谢物
三甲胺
心脏病学
胃肠病学
生物信息学
内分泌学
病理
生物化学
免疫学
生物
作者
Antonio Cittadini,Shabana Cassambai,Yoshiyuki Yazaki,Muhammad Israr,Dennis Bernieh,Max Wong,Toru Suzuki
标识
DOI:10.1016/j.ccl.2021.12.004
摘要
A novel pathophysiological model of interest is the association between heart failure (HF) and the gastrointestinal system, the 'gut hypothesis'. The choline and carnitine metabolic by-product, Trimethylamine N-oxide (TMAO) is one of the more prominent molecules associated with the link between HF and the gut. Indeed, TMAO levels are increased in HF populations and higher TMAO levels are associated with poor prognosis, whereas low TMAO levels either at baseline/follow up confer better prognosis. Considering that TMAO levels seem not to be affected by guideline-HF treatment, this model could represent a novel and independent therapeutic target for HF.
科研通智能强力驱动
Strongly Powered by AbleSci AI