Exosomes as Radiation Biomarkers

Exosomes are now considered as important mediators of intercellular communication. The exosome cargo contains proteins; mRNA, microRNA (miRNA) and DNA that delivers the information between one cell to other cells can play an important role in identifying the pathophysiological conditions of any cell. Increased understanding of mechanism about exosome release and its communication could provide a novel strategy for the development of biomarkers in various health conditions. Recent shreds of evidence revealed that radiation induces the secretion and alters the composition of exosomes released from radiated cells. The exosomes released from radiated cells alters the signaling pathways in recipient cells. Unraveling the mechanisms related to radiation and exosomes would shed light on the unknown factors that are involved in radiation-induced non-targeted effects. This can provide pavement for the development of biomarkers in radiation emergency situations.KeywordsExosomesRadiationmiRNAGenomic instability