Photoinduced nickel-catalyzed enantioselective coupling reactions

The merger of nickel catalysis and photocatalysis has emerged as a transformative platform for the rapid assembly of molecular complexity from readily available building blocks under remarkably mild conditions. This strategy can readily convert abundant native functionality into radical species through photoinduced single-electron activation, and subsequent engages the resultant open-shell radicals in nickel-catalyzed fragment cross-coupling reactions to enable previously challenging chemical bond formation. Although significant progress has been achieved towards expanding the toolbox of coupling partners, the development of enantioselective transformations in nickel photoredox catalysis is still challenging and in high demand. Recent advances have demonstrated such transformations can be rendered enantioselective and hold great promise to provides orthogonal approaches to the streamlined synthesis of enantioenriched chiral compounds. This review comprehensively summarized and discusses recent progress in photoinduced nickel-catalyzed enantioselective transformations with an emphasis on the reaction achievements, mechanistic insights, and structural characteristics of chiral ligands.