硫醚
氮族元素
环番
化学
组合化学
动态共价化学
二硫键
自组装
有机化学
超分子化学
分子
超导电性
生物化学
量子力学
物理
作者
Trevor A. Shear,Jacob T. Mayhugh,Luca J. Zocchi,Isabella S. Demachkie,Henry J. Trubinstein,Lev N. Zakharov,Darren W. Johnson
标识
DOI:10.1002/ejoc.202200056
摘要
Abstract Cyclophanes are a fundamentally interesting class of compounds that host a wide range of unique and emergent properties. However, synthesis of complex and/or functionalized cyclophanes can often suffer from harsh reaction conditions, long reaction times, and sometimes low yields using stepwise methods. We have previously reported an efficient, high‐yielding, metalloid‐directed self‐assembly method to prepare disulfide, thioether, and hydrocarbon cyclophanes and cages that feature mercaptomethyl‐arenes as starting materials. Herein, we report the synthesis of 21 new disulfide and thioether assemblies that expand this high yielding self‐assembly method to a wide breadth of macrocycles and cages with diverse structures. Remarkably, the high‐yielding, efficient syntheses still proceed under dynamic covalent control using electron‐deficient, heteroaryl, cycloalkyl, spiro, and even short alkenyl/alkynyl substrates.
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