化学
催化作用
电化学
检出限
铱
选择性
生物分子
电化学气体传感器
组合化学
纳米技术
作者
Xin Luo,Zhen Luo,Xiaoqian Wei,Lei Jiao,Qie Fang,Hengjia Wang,Jing Wang,Wenling Gu,Liuyong Hu,Chengzhou Zhu
标识
DOI:10.1021/acs.analchem.1c04665
摘要
Tremendous efforts have been made in developing single-atomic site catalysts (SASCs) for oxygen reduction reaction (ORR), which is regarded as a pivotal cornerstone in electrochemical energy conversion. However, SASCs for ORR have not been explored for electrochemical sensing. Herein, a template-sacrificed strategy is reported for the synthesis of atomically dispersed Ir SASCs, serving as a sensing platform to detect organophosphorus pesticides (OPs) with high sensitivity and selectivity. Owing to abundant Ir single-atom active sites, Ir SASCs show excellent ORR activity and stability in a neutral medium. It is found that the ORR activity of Ir SASCs can be inhibited by thiocholine, which is the hydrolysate of acetylthiocholine. After being integrated with acetylcholinesterase (AChE), the AChE-Ir SASC-based electrochemical sensor is established and shows a superior sensitivity, which shows a wide detection range of 0.5-500 ng mL-1 with a low detection limit of 0.17 ng mL-1 for OPs. This work exhibits a broad application prospect of ORR for sensitive detection of biomolecules.
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